adavosertib


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122 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 WEE1 G2 checkpoint kinase WEE1_HUMAN WEE1 Homo sapiens 7465 177 166
2 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 25
3 cyclin dependent kinase 1 CDK1_HUMAN CDK1 Homo sapiens 983 1023 23
4 WEE 1 homolog 1 (S. pombe) WEE1_MOUSE Wee1 Mus musculus 22390 28 14
5 checkpoint kinase 1 CHK1_HUMAN CHEK1 Homo sapiens 1111 648 12
6 polo like kinase 1 PLK1_HUMAN PLK1 Homo sapiens 5347 475 7
7 cyclin dependent kinase 2 CDK2_HUMAN CDK2 Homo sapiens 1017 1201 5
8 H2A.X variant histone H2AX_HUMAN H2AX Homo sapiens 3014 412 5
9 BRCA1 DNA repair associated BRCA1_HUMAN BRCA1 Homo sapiens 672 696 4
10 RAD51 recombinase RAD51_HUMAN RAD51 Homo sapiens 5888 537 3
11 myelin transcription factor 1 MYT1_HUMAN MYT1 Homo sapiens 4661 42 3
12 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 3
13 cyclin dependent kinase 12 CDK12_HUMAN CDK12 Homo sapiens 51755 58 3
14 ATR serine/threonine kinase ATR_HUMAN ATR Homo sapiens 545 866 3
15 MCL1 apoptosis regulator, BCL2 family member MCL1_HUMAN MCL1 Homo sapiens 4170 1015 3
16 transformation related protein 53 P53_MOUSE Trp53 Mus musculus 22059 281 3
17 KRAS proto-oncogene, GTPase RASK_HUMAN KRAS Homo sapiens 3845 1547 2
18 poly(ADP-ribose) polymerase 1 PARP1_HUMAN PARP1 Homo sapiens 142 2571 2
19 ataxia telangiectasia mutated ATM_MOUSE Atm Mus musculus 11920 222 2
20 caspase 3 CASP3_HUMAN CASP3 Homo sapiens 836 5209 2
21 cyclin-dependent kinase 1 CDK1_MOUSE Cdk1 Mus musculus 12534 208 2
22 MUS81 structure-specific endonuclease subunit MUS81_HUMAN MUS81 Homo sapiens 80198 37 2
23 DNA damage inducible transcript 3 DDIT3_HUMAN DDIT3 Homo sapiens 1649 1082 2
24 Kirsten rat sarcoma viral oncogene homolog RASK_MOUSE Kras Mus musculus 16653 464 2
25 H2A.X variant histone H2AX_MOUSE H2ax Mus musculus 15270 247 2
26 MYC proto-oncogene, bHLH transcription factor MYC_HUMAN MYC Homo sapiens 4609 2261 2
27 ATRX chromatin remodeler ATRX_HUMAN ATRX Homo sapiens 546 85 2
28 DNA polymerase lambda DPOLL_HUMAN POLL Homo sapiens 27343 176 1
29 ATM serine/threonine kinase ATM_HUMAN ATM Homo sapiens 472 847 1
30 syndecan 1 SDC1_HUMAN SDC1 Homo sapiens 6382 265 1
31 von Hippel-Lindau tumor suppressor VHL_HUMAN VHL Homo sapiens 7428 215 1
32 neurofibromin 1 NF1_HUMAN NF1 Homo sapiens 4763 413 1
33 H2B clustered histone 21 H2B2E_HUMAN H2BC21 Homo sapiens 8349 181 1
34 H3 histone pseudogene 16 - H3P16 Homo sapiens 644914 2095 1
35 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 1
36 phosphoglycolate phosphatase PGP_MOUSE Pgp Mus musculus 67078 756 1
37 poly (ADP-ribose) polymerase family, member 1 Q921K2_MOUSE Parp1 Mus musculus 11545 842 1
38 transformation related protein 53, pseudogene - Trp53-ps Mus musculus 22060 1552 1
39 BRCA2 DNA repair associated BRCA2_HUMAN BRCA2 Homo sapiens 675 305 1
40 myelocytomatosis oncogene MYC_MOUSE Myc Mus musculus 17869 289 1
41 SRC proto-oncogene, non-receptor tyrosine kinase SRC_HUMAN SRC Homo sapiens 6714 2142 1
42 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 1
43 eukaryotic translation initiation factor 2 alpha kinase 3 E2AK3_HUMAN EIF2AK3 Homo sapiens 9451 737 1
44 protein kinase, DNA-activated, catalytic subunit PRKDC_HUMAN PRKDC Homo sapiens 5591 418 1
45 aldehyde dehydrogenase 1 family member A1 AL1A1_HUMAN ALDH1A1 Homo sapiens 216 347 1
46 ATP binding cassette subfamily G member 2 (Junior blood group) ABCG2_HUMAN ABCG2 Homo sapiens 9429 1370 1
47 ribonucleotide reductase M2 RIR2_MOUSE Rrm2 Mus musculus 20135 38 1
48 poly(ADP-ribose) polymerase family member 16 PAR16_HUMAN PARP16 Homo sapiens 54956 24 1
49 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 1
50 isocitrate dehydrogenase (NADP(+)) 2 IDHP_HUMAN IDH2 Homo sapiens 3418 163 1