Protein Name ATR serine/threonine kinase
Organism Homo sapiens
Gene ID 545
Gene Symbol


UniProt Q13535 (ATR_HUMAN)
Relationships Total Number of functionally related compound(s) : 866
Total Number of Articles : 1248

ATR serine/threonine kinase

Gene Summary

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

  • serine/threonine-protein kinase ATR
  • FRAP-related protein-1
  • MEC1, mitosis entry checkpoint 1, homolog
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