| Protein Name | ataxia telangiectasia mutated |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11920 |
| Gene Symbol | Atm |
| UniProt | Q62388 (ATM_MOUSE), B9EHX4 (B9EHX4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
222
Total Number of Articles : 319 |
Description |
ataxia telangiectasia mutated |
| Gene Summary |
Enables histone H2AXS139 kinase activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of TORC1 signaling; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including immune system development; intracellular signal transduction; and meiotic nuclear division. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is extrinsic component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |