| Protein Name | isocitrate dehydrogenase (NADP(+)) 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3418 |
| Gene Symbol | IDH2 |
| UniProt | P48735 (IDHP_HUMAN), B4DSZ6 (B4DSZ6_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
163
Total Number of Articles : 305 |
Description |
isocitrate dehydrogenase (NADP(+)) 2 |
| Gene Summary |
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| synonyms |
|
| Properties | |