Protein Name syndecan 1
Organism Homo sapiens
Gene ID 6382
Gene Symbol


UniProt P18827 (SDC1_HUMAN)
Relationships Total Number of functionally related compound(s) : 265
Total Number of Articles : 427

syndecan 1

Gene Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

  • syndecan-1
  • CD138 antigen
  • heparan sulfate proteoglycan fibroblast growth factor receptor
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