Protein Name cyclin dependent kinase 1
Organism Homo sapiens
Gene ID 983
Gene Symbol


UniProt P06493 (CDK1_HUMAN), A0A024QZJ8 (A0A024QZJ8_HUMAN), B7Z3D6 (B7Z3D6_HUMAN), I6L9I5 (I6L9I5_HUMAN)
Relationships Total Number of functionally related compound(s) : 1023
Total Number of Articles : 1973

cyclin dependent kinase 1

Gene Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023]

  • cyclin-dependent kinase 1
  • cell cycle controller CDC2
  • cell division control protein 2 homolog
Click to show/hide the synonyms