Protein Name polo like kinase 1
Organism Homo sapiens
Gene ID 5347
Gene Symbol


UniProt P53350 (PLK1_HUMAN)
Relationships Total Number of functionally related compound(s) : 475
Total Number of Articles : 766

polo like kinase 1

Gene Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]

  • serine/threonine-protein kinase PLK1
  • PLK-1
  • cell cycle regulated protein kinase
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