| Protein Name | poly (ADP-ribose) polymerase family, member 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11545 |
| Gene Symbol | Parp1 |
| UniProt | Q921K2 (Q921K2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
842
Total Number of Articles : 1306 |
Description |
poly (ADP-ribose) polymerase family, member 1 |
| Gene Summary |
Enables NAD+ ADP-ribosyltransferase activity; chromatin binding activity; and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening; positive regulation of single strand break repair; and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and protein poly-ADP-ribosylation. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch; brain; gut; immune system; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Apr 2022] |
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