MLN 8237


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83 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 aurora kinase A AURKA_HUMAN AURKA Homo sapiens 6790 433 110
2 aurora kinase A AURKA_MOUSE Aurka Mus musculus 20878 82 15
3 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 9
4 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 8
5 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 6
6 mitogen-activated protein kinase 14 MK14_HUMAN MAPK14 Homo sapiens 1432 3132 5
7 MYC proto-oncogene, bHLH transcription factor MYC_HUMAN MYC Homo sapiens 4609 2261 4
8 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 3
9 MYCN proto-oncogene, bHLH transcription factor MYCN_HUMAN MYCN Homo sapiens 4613 374 3
10 cytochrome P450 family 3 subfamily A member 4 CP3A4_HUMAN CYP3A4 Homo sapiens 1576 3475 3
11 BH3 interacting domain death agonist BID_HUMAN BID Homo sapiens 637 1130 2
12 myelocytomatosis oncogene MYC_MOUSE Myc Mus musculus 17869 289 2
13 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 2
14 poly(ADP-ribose) polymerase 1 PARP1_HUMAN PARP1 Homo sapiens 142 2571 2
15 v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived MYCN_MOUSE Mycn Mus musculus 18109 102 2
16 transformation related protein 53, pseudogene - Trp53-ps Mus musculus 22060 1552 2
17 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 2
18 enhancer of zeste 2 polycomb repressive complex 2 subunit EZH2_HUMAN EZH2 Homo sapiens 2146 470 2
19 translocated promoter region, nuclear basket protein TPR_HUMAN TPR Homo sapiens 7175 238 1
20 triosephosphate isomerase 1 TPIS_HUMAN TPI1 Homo sapiens 7167 355 1
21 cytochrome P450 family 2 subfamily C member 19 CP2CJ_HUMAN CYP2C19 Homo sapiens 1557 1098 1
22 cytochrome P450 family 2 subfamily C member 9 CP2C9_HUMAN CYP2C9 Homo sapiens 1559 1244 1
23 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 1
24 MCL1 apoptosis regulator, BCL2 family member MCL1_HUMAN MCL1 Homo sapiens 4170 1015 1
25 BRCA2 DNA repair associated BRCA2_HUMAN BRCA2 Homo sapiens 675 305 1
26 phosphoglycolate phosphatase PGP_MOUSE Pgp Mus musculus 67078 756 1
27 cytochrome P450 family 2 subfamily C member 8 CP2C8_HUMAN CYP2C8 Homo sapiens 1558 590 1
28 polo like kinase 1 PLK1_HUMAN PLK1 Homo sapiens 5347 475 1
29 von Hippel-Lindau tumor suppressor VHL_HUMAN VHL Homo sapiens 7428 215 1
30 ATM serine/threonine kinase ATM_HUMAN ATM Homo sapiens 472 847 1
31 sirtuin 1 SIR1_HUMAN SIRT1 Homo sapiens 23411 1253 1
32 ATP binding cassette subfamily C member 1 MRP1_HUMAN ABCC1 Homo sapiens 4363 1125 1
33 ATP binding cassette subfamily G member 2 (Junior blood group) ABCG2_HUMAN ABCG2 Homo sapiens 9429 1370 1
34 tumor protein p73 P73_HUMAN TP73 Homo sapiens 7161 217 1
35 transformation related protein 53 P53_MOUSE Trp53 Mus musculus 22059 281 1
36 catenin beta 1 CTNB1_HUMAN CTNNB1 Homo sapiens 1499 2350 1
37 ribosomal protein S6 kinase B1 KS6B1_HUMAN RPS6KB1 Homo sapiens 6198 764 1
38 CD274 molecule PD1L1_HUMAN CD274 Homo sapiens 29126 1115 1
39 B cell leukemia/lymphoma 2 BCL2_MOUSE Bcl2 Mus musculus 12043 1497 1
40 DNA methyltransferase 1 DNMT1_HUMAN DNMT1 Homo sapiens 1786 621 1
41 mitogen-activated protein kinase 3 MK03_MOUSE Mapk3 Mus musculus 26417 1527 1
42 cyclin dependent kinase 4 CDK4_HUMAN CDK4 Homo sapiens 1019 868 1
43 signal transducer and activator of transcription 3 STAT3_MOUSE Stat3 Mus musculus 20848 1288 1
44 MDM2 proto-oncogene MDM2_HUMAN MDM2 Homo sapiens 4193 873 1
45 Janus kinase 2 JAK2_HUMAN JAK2 Homo sapiens 3717 1038 1
46 eukaryotic translation initiation factor 4E IF4E_MOUSE Eif4e Mus musculus 13684 78 1
47 signal transducer and activator of transcription 1 Q8C3V4_MOUSE Stat1 Mus musculus 20846 383 1
48 glycogen synthase kinase 3 beta GSK3B_HUMAN GSK3B Homo sapiens 2932 1189 1
49 lysine demethylase 6B KDM6B_HUMAN KDM6B Homo sapiens 23135 93 1
50 CD274 antigen PD1L1_MOUSE Cd274 Mus musculus 60533 466 1