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490 Functionally related protein(s)
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Protein Name
UniProt Entry
Gene Symbol
Organism
NCBI Gene ID
# All related compound(s)
#Article(s)
1 ATM serine/threonine kinase ATM_HUMAN ATM Homo sapiens 472 847 90
2 H2A.X variant histone H2AX_HUMAN H2AX Homo sapiens 3014 412 48
3 protein kinase, DNA-activated, catalytic subunit PRKDC_HUMAN PRKDC Homo sapiens 5591 418 30
4 tumor protein p53 binding protein 1 TP53B_HUMAN TP53BP1 Homo sapiens 7158 156 29
5 H2A.X variant histone H2AX_MOUSE H2ax Mus musculus 15270 247 28
6 MRE11 homolog, double strand break repair nuclease MRE11_HUMAN MRE11 Homo sapiens 4361 104 28
7 nibrin NBN_HUMAN NBN Homo sapiens 4683 703 27
8 RAD51 recombinase RAD51_HUMAN RAD51 Homo sapiens 5888 537 22
9 ATR serine/threonine kinase ATR_HUMAN ATR Homo sapiens 545 866 21
10 RB binding protein 8, endonuclease CTIP_HUMAN RBBP8 Homo sapiens 5932 60 20
11 RAD50 double strand break repair protein RAD50_HUMAN RAD50 Homo sapiens 10111 70 18
12 ataxia telangiectasia mutated ATM_MOUSE Atm Mus musculus 11920 222 17
13 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 15
14 SPO11 initiator of meiotic double stranded breaks SPO11_MOUSE Spo11 Mus musculus 26972 13 12
15 MRX complex nuclease subunit MRE11_YEAST MRE11 Saccharomyces cerevisiae S288C 855264 35 11
16 mediator of DNA damage checkpoint 1 MDC1_HUMAN MDC1 Homo sapiens 9656 57 10
17 DNA topoisomerase (ATP-hydrolyzing) SPO11_YEAST SPO11 Saccharomyces cerevisiae S288C 856364 14 10
18 poly(ADP-ribose) polymerase 1 PARP1_HUMAN PARP1 Homo sapiens 142 2571 10
19 recombinase RAD51 RAD51_YEAST RAD51 Saccharomyces cerevisiae S288C 856831 54 9
20 BRCA1 DNA repair associated BRCA1_HUMAN BRCA1 Homo sapiens 672 696 9
21 MRE11A homolog A, double strand break repair nuclease MRE11_MOUSE Mre11a Mus musculus 17535 17 8
22 checkpoint kinase 2 CHK2_HUMAN CHEK2 Homo sapiens 11200 417 8
23 activation induced cytidine deaminase AICDA_HUMAN AICDA Homo sapiens 57379 912 8
24 transformation related protein 53, pseudogene - Trp53-ps Mus musculus 22060 1552 7
25 SPO11 initiator of meiotic double stranded breaks SPO11_HUMAN SPO11 Homo sapiens 23626 7 7
26 checkpoint kinase 1 CHK1_HUMAN CHEK1 Homo sapiens 1111 648 7
27 X-ray repair cross complementing 6 XRCC6_HUMAN XRCC6 Homo sapiens 2547 113 7
28 MRX complex DNA-binding subunit RAD50_YEAST RAD50 Saccharomyces cerevisiae S288C 855471 26 6
29 protein kinase MEC1 ATR_YEAST MEC1 Saccharomyces cerevisiae S288C 852433 51 6
30 exonuclease 1 EXO1_HUMAN EXO1 Homo sapiens 9156 169 6
31 non-homologous end joining factor 1 NHEJ1_HUMAN NHEJ1 Homo sapiens 79840 14 6
32 WRN RecQ like helicase WRN_HUMAN WRN Homo sapiens 7486 126 6
33 X-ray repair cross complementing 4 XRCC4_HUMAN XRCC4 Homo sapiens 7518 66 6
34 Xrs2p XRS2_YEAST XRS2 Saccharomyces cerevisiae S288C 851975 18 6
35 immunoglobulin heavy constant delta - IGHD Homo sapiens 3495 30 6
36 recombinase RAD52 RAD52_YEAST RAD52 Saccharomyces cerevisiae S288C 854976 66 6
37 DNA ligase 4 DNLI4_HUMAN LIG4 Homo sapiens 3981 89 5
38 CCCTC-binding factor CTCF_HUMAN CTCF Homo sapiens 10664 127 5
39 DNA ligase (ATP) DNL4 DNLI4_YEAST DNL4 Saccharomyces cerevisiae S288C 854166 5 5
40 RAD51 recombinase RAD51_MOUSE Rad51 Mus musculus 19361 68 5
41 protein kinase, DNA activated, catalytic polypeptide PRKDC_MOUSE Prkdc Mus musculus 19090 100 5
42 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 SMCA5_HUMAN SMARCA5 Homo sapiens 8467 27 5
43 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 5
44 activation-induced cytidine deaminase AICDA_MOUSE Aicda Mus musculus 11628 61 4
45 X-ray repair cross complementing 5 XRCC5_HUMAN XRCC5 Homo sapiens 7520 112 4
46 BP1 - BP1 Homo sapiens 474256 152 4
47 ssDNA endodeoxyribonuclease SAE2 COM1_YEAST SAE2 Saccharomyces cerevisiae S288C 852700 15 4
48 Lif1p LIF1_YEAST LIF1 Saccharomyces cerevisiae S288C 852790 6 4
49 BRCA2 DNA repair associated BRCA2_HUMAN BRCA2 Homo sapiens 675 305 4
50 ligase IV, DNA, ATP-dependent DNLI4_MOUSE Lig4 Mus musculus 319583 10 4