| Protein Name | mediator of DNA damage checkpoint 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9656 |
| Gene Symbol | MDC1 |
| UniProt | Q14676 (MDC1_HUMAN), A0A1U9XBC1 (A0A1U9XBC1_HUMAN), A1Z5I9 (A1Z5I9_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
57
Total Number of Articles : 78 |
Description |
mediator of DNA damage checkpoint 1 |
| Gene Summary |
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008] |
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| Properties | |