Protein Name X-ray repair cross complementing 5
Organism Homo sapiens
Gene ID 7520
Gene Symbol

XRCC5

UniProt P13010 (XRCC5_HUMAN)
Relationships Total Number of functionally related compound(s) : 112
Total Number of Articles : 128
Description

X-ray repair cross complementing 5

Gene Summary

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

synonyms
  • X-ray repair cross-complementing protein 5
  • 86 kDa subunit of Ku antigen
  • ATP-dependent DNA helicase 2 subunit 2
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Properties