| Protein Name | tumor protein p53 binding protein 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7158 |
| Gene Symbol | TP53BP1 |
| UniProt | Q12888 (TP53B_HUMAN), A6NNK5 (A6NNK5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
156
Total Number of Articles : 206 |
Description |
tumor protein p53 binding protein 1 |
| Gene Summary |
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
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