Protein Name MRE11A homolog A, double strand break repair nuclease
Organism Mus musculus
Gene ID 17535
Gene Symbol

Mre11a

UniProt Q61216 (MRE11_MOUSE), Q3URU4 (Q3URU4_MOUSE), Q8BRV3 (Q8BRV3_MOUSE), Q3TU24 (Q3TU24_MOUSE)
Relationships Total Number of functionally related compound(s) : 17
Total Number of Articles : 19
Description

MRE11A homolog A, double strand break repair nuclease

Gene Summary

Enables nuclease activity. Involved in DNA strand resection involved in replication fork processing; chromosome organization; and double-strand break repair via homologous recombination. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Part of Mre11 complex. Colocalizes with chromosome, telomeric region. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • double-strand break repair protein MRE11
  • MRE11 homolog 1
  • MRE11 homolog A
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Properties