Protein Name protein kinase, DNA activated, catalytic polypeptide
Organism Mus musculus
Gene ID 19090
Gene Symbol

Prkdc

UniProt P97313 (PRKDC_MOUSE)
Relationships Total Number of functionally related compound(s) : 100
Total Number of Articles : 115
Description

protein kinase, DNA activated, catalytic polypeptide

Gene Summary

Enables DNA-dependent protein kinase activity; double-stranded DNA binding activity; and enzyme binding activity. Involved in several processes, including regulation of hematopoietic stem cell differentiation; regulation of hemopoiesis; and regulation of protein metabolic process. Acts upstream of or within several processes, including DNA metabolic process; ectopic germ cell programmed cell death; and hemopoiesis. Located in nucleus. Is expressed in several structures, including central nervous system; liver; neural retina; and thymus primordium. Used to study Duchenne muscular dystrophy; severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • DNA-dependent protein kinase catalytic subunit
  • DNA-PK catalytic subunit
  • doxorubicin nephropathy
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Properties