Protein Name activation induced cytidine deaminase
Organism Homo sapiens
Gene ID 57379
Gene Symbol


UniProt Q9GZX7 (AICDA_HUMAN), Q546Y9 (Q546Y9_HUMAN), Q6QJ80 (Q6QJ80_HUMAN), Q7Z599 (Q7Z599_HUMAN)
Relationships Total Number of functionally related compound(s) : 912
Total Number of Articles : 1392

activation induced cytidine deaminase

Gene Summary

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul 2020]

  • single-stranded DNA cytosine deaminase
  • cytidine aminohydrolase
  • epididymis secretory protein Li 284
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