CPRiL

MRE11

MRE11 double strand break repair nuclease

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• double-strand break repair protein MRE11
• AT-like disease
• DNA recombination and repair protein
MRE11 double strand break repair nuclease A
MRE11 homolog 1
MRE11 homolog A, double strand break repair nuclease
MRE11 homolog, double strand break repair nuclease A
MRE11 meiotic recombination 11 homolog A
MRE11 meiotic recombination 11-like protein A
double-strand break repair protein MRE11A
endo/exonuclease Mre11
meiotic recombination 11 homolog 1
meiotic recombination 11 homolog A
ATLD
HNGS1
MRE11A
MRE11B