CPRiL

WRN

WRN RecQ like helicase

This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

• bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
• DNA helicase, RecQ-like type 3
• Werner syndrome ATP-dependent helicase
Werner syndrome RecQ like helicase
Werner syndrome protein
Werner syndrome, RecQ helicase-like
exonuclease WRN
recQ protein-like 2
RECQ3
RECQL2
RECQL3