ATP binding cassette subfamily C member 5 ; Homo sapiens






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1 10438534 pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells. J Biol Chem 1999 Aug 13 5
2 10728601 Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer. Int J Cancer 2000 Apr 1 5
3 10840050 Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci U S A 2000 Jun 20 8
4 10893247 The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem 2000 Sep 29 8
5 11641044 Enhancement of the activity of doxorubicin by inhibition of glutamate transporter. Toxicol Lett 2001 Sep 15 1
6 11745426 Induction of MRP5 and SMRP mRNA by adriamycin exposure and its overexpression in human lung cancer cells resistant to adriamycin. Int J Cancer 2001 Nov 1 17
7 11766988 The MRP family and anticancer drug metabolism. Curr Drug Metab 2001 Dec 5
8 11804191 MRP subfamily transporters and resistance to anticancer agents. J Bioenerg Biomembr 2001 Dec 4
9 11956491 Immunolocalization of multidrug resistance protein 5 in the human genitourinary system. J Urol 2002 May 13
10 12423063 Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci 2002 5
11 12435799 Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol Pharmacol 2002 Dec 15
12 12441801 Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS 2002 Nov 22 3
13 12637526 Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem 2003 May 16 10
14 12679160 Expression of multidrug resistance protein 4 and 5 in the porcine coronary and pulmonary arteries. Eur J Pharmacol 2003 Apr 11 2
15 12695538 Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol 2003 May 7
16 12897433 Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate. Biofactors 2003 3
17 14507663 Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. Am J Pathol 2003 Oct 11
18 15025427 Reconstitution of ATP-dependent cGMP transport into proteoliposomes by membrane proteins from human erythrocytes. Scand J Clin Lab Invest 2004 1
19 15072547 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol 2004 Apr 1
20 15312981 Cyclic GMP transporters. Neurochem Int 2004 Nov 1
21 15345330 Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters. Biochem Pharmacol 2004 Oct 1 2
22 15456083 ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther 2004 Aug 2
23 15501592 Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience 2004 4
24 15631998 Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. Am J Pathol 2005 Jan 13
25 15747503 Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev 2005 3
26 15794947 cGMP (guanosine 3',5'-cyclic monophosphate) transport across human erythrocyte membranes. Biochem Pharmacol 2005 Apr 15 1
27 15845416 Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins. Toxicol Appl Pharmacol 2005 May 1 1
28 15861033 Strong linkage disequilibrium at the nucleotide analogue transporter ABCC5 gene locus. Pharmacogenet Genomics 2005 Feb 2
29 15882455 ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines. Mol Cancer 2005 May 9 1
30 15897250 The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol Cancer Ther 2005 May 20
31 15899835 The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res 2005 May 15 18
32 16156793 Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5). FEBS J 2005 Sep 7
33 16337112 Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci 2006 Apr 20
34 16508919 Expression of drug pathway proteins is independent of tumour type. J Pathol 2006 Jun 1
35 16516478 Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport? Bioorg Med Chem 2006 Jul 1 1
36 16614078 Contribution of multidrug resistance protein MRP5 in control of cyclic guanosine 5'-monophosphate intracellular signaling in anterior pituitary cells. Endocrinology 2006 Jul 5
37 16868766 ABCC10, ABCC11, and ABCC12. Pflugers Arch 2007 Feb 4
38 16891466 The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity. Mol Cancer Ther 2006 Jul 10
39 17518506 Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy. Clin Pharmacokinet 2007 4
40 17540771 Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem 2007 Jul 20 12
41 17579998 Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): origin of resistance. Folia Biol (Praha) 2007 1
42 17661346 The Role of heat shock protein 27 in extravillous trophoblast differentiation. J Cell Biochem 2008 Feb 15 2
43 17803828 Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5). Theor Biol Med Model 2007 Sep 6 3
44 18250047 [Detection of multidrug resistance-associated proteins MRP2, MRP3, and MRP5 mRNA expressions in hepatocarcinoma cells using SYBR real-time PCR]. Nan Fang Yi Ke Da Xue Xue Bao 2008 Feb 1
45 18690847 Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets 2008 Aug 6
46 19077464 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology 2009 4
47 19177904 Characterization of multidrug resistance-associated protein mRNAs expression profiles in Caco-2 and HT-1080 cell lines induced by methotrexate. Pharmazie 2008 Dec 1
48 19323627 Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux. J Ocul Pharmacol Ther 2009 Apr 6
49 19384462 Efflux protein expression in human retinal pigment epithelium cell lines. Pharm Res 2009 Jul 5
50 19566819 Multidrug resistance-associated proteins and implications in drug development. Clin Exp Pharmacol Physiol 2010 Jan 1