Pub. Date : 2003 May 16
PMID : 12637526
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. | Nucleotides, Cyclic | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | Two recently described members of the multidrug resistance protein family, MRP4 and MRP5, might be involved in this process, because they transport the 3",5"-cyclic nucleotides, cAMP and cGMP, into inside-out membrane vesicles. | 3",5"-cyclic nucleotides | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | Two recently described members of the multidrug resistance protein family, MRP4 and MRP5, might be involved in this process, because they transport the 3",5"-cyclic nucleotides, cAMP and cGMP, into inside-out membrane vesicles. | Cyclic AMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | Two recently described members of the multidrug resistance protein family, MRP4 and MRP5, might be involved in this process, because they transport the 3",5"-cyclic nucleotides, cAMP and cGMP, into inside-out membrane vesicles. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | MRP4- and MRP5-overexpressing cells effluxed more cGMP and cAMP than parental cells in an ATP-dependent manner. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | MRP4- and MRP5-overexpressing cells effluxed more cGMP and cAMP than parental cells in an ATP-dependent manner. | Cyclic AMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | MRP4- and MRP5-overexpressing cells effluxed more cGMP and cAMP than parental cells in an ATP-dependent manner. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 8 | The efflux mediated by MRP4 and MRP5 did not lead to a proportional decrease in the intracellular cGMP or cAMP levels but reduced cGMP by maximally 2-fold over the first hour. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 9 | These data indicate that MRP4 and MRP5 are low affinity cyclic nucleotide transporters that may at best function as overflow pumps, decreasing steep increases in cGMP levels under conditions where cGMP synthesis is strongly induced and phosphodiesterase activity is limiting. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 10 | These data indicate that MRP4 and MRP5 are low affinity cyclic nucleotide transporters that may at best function as overflow pumps, decreasing steep increases in cGMP levels under conditions where cGMP synthesis is strongly induced and phosphodiesterase activity is limiting. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |