Pub. Date : 2000 Apr 1
PMID : 10728601
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer. | Platinum | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | To investigate the role of the multidrug resistance-associated protein (MRP1) homologue MRP5 in relation to platinum drug resistance, we examined the steady-state levels of the mRNAs for MRP5 in both lung cancer cell lines and peripheral mononuclear cells (PMN) after exposure to platinum drug and in normal lung and lung cancer tissue specimens. | Platinum | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | Next, we monitored MRP5 gene expression levels within 24 hr in both lung cancer cell lines incubated with cisplatin and in PMN from 10 previously untreated lung cancer patients after carboplatin administration alone. | Cisplatin | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | The MRP5 expression levels in normal lung tissues and in tumors from patients exposed to platinum drugs during their lifetime were significantly higher than those in tissues from non-exposed patients. | Platinum | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | Our results suggest that increased expression levels of the MRP5 gene are associated with exposure to platinum drugs in lung cancer in vivo and/or the chronic stress response to xenobiotics. | Platinum | ATP binding cassette subfamily C member 5 | Homo sapiens |