Pub. Date : 2000 Jun 20
PMID : 10840050
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found resistance against the thiopurine anticancer drugs, 6-mercaptopurine (6-MP) and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in MRP5-transfected cells. | adefovir | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | This resistance is due to an increased extrusion of PMEA and 6-thioinosine monophosphate from the cells that overproduce MRP5. | adefovir | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | This resistance is due to an increased extrusion of PMEA and 6-thioinosine monophosphate from the cells that overproduce MRP5. | 6-thioinosine monophosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | In polarized Madin-Darby canine kidney II (MDCKII) cells transfected with an MRP5 cDNA construct, MRP5 is routed to the basolateral membrane and these cells transport S-(2,4-dinitrophenyl)glutathione and glutathione preferentially toward the basal compartment. | S-(2,4-dinitrophenyl)glutathione | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | In polarized Madin-Darby canine kidney II (MDCKII) cells transfected with an MRP5 cDNA construct, MRP5 is routed to the basolateral membrane and these cells transport S-(2,4-dinitrophenyl)glutathione and glutathione preferentially toward the basal compartment. | S-(2,4-dinitrophenyl)glutathione | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | In polarized Madin-Darby canine kidney II (MDCKII) cells transfected with an MRP5 cDNA construct, MRP5 is routed to the basolateral membrane and these cells transport S-(2,4-dinitrophenyl)glutathione and glutathione preferentially toward the basal compartment. | Glutathione | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | In polarized Madin-Darby canine kidney II (MDCKII) cells transfected with an MRP5 cDNA construct, MRP5 is routed to the basolateral membrane and these cells transport S-(2,4-dinitrophenyl)glutathione and glutathione preferentially toward the basal compartment. | Glutathione | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 8 | We speculate that MRP5 might play a role in some cases of unexplained resistance to thiopurines in acute lymphoblastic leukemia and/or to antiretroviral nucleoside analogs in HIV-infected patients. | thiopurines | ATP binding cassette subfamily C member 5 | Homo sapiens |