Pub. Date : 2003 May
PMID : 12695538
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. | Nucleosides | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters that have the unusual ability to transport cyclic nucleotides and some nucleoside monophosphate analogs. | Nucleotides, Cyclic | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters that have the unusual ability to transport cyclic nucleotides and some nucleoside monophosphate analogs. | nucleoside monophosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | In cytotoxicity assays, MRP4 conferred resistance to the antiviral agent 9-(2-phosphonomethoxyethyl)adenine (PMEA) and high-performance liquid chromatography analysis showed that, like MRP5, MRP4 transported PMEA in an unmodified form. | adefovir | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | Moreover, only inside-out membrane vesicles derived from MRP5-overexpressing cells accumulated alaninyl-d4TMP. | alaninyl-d4tmp | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | Cellular efflux and vesicular uptake studies were carried out to further compare transport mediated by MRP4 and MRP5 and showed that dipyridamole, dilazep, nitrobenzyl mercaptopurine riboside, sildenafil, trequinsin and MK571 inhibited MRP4 more than MRP5, whereas cyclic nucleotides and monophosphorylated nucleoside analogs were equally poor inhibitors of both pumps. | nitrobenzyl mercaptopurine riboside | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | Cellular efflux and vesicular uptake studies were carried out to further compare transport mediated by MRP4 and MRP5 and showed that dipyridamole, dilazep, nitrobenzyl mercaptopurine riboside, sildenafil, trequinsin and MK571 inhibited MRP4 more than MRP5, whereas cyclic nucleotides and monophosphorylated nucleoside analogs were equally poor inhibitors of both pumps. | Sildenafil Citrate | ATP binding cassette subfamily C member 5 | Homo sapiens |