Pub. Date : 2006 Jul
PMID : 16891466
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity. | gemcitabine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | We examined the expression levels of the multidrug resistance protein 5 (ABCC5) gene in non-small cell lung cancer (NSCLC) cell lines to clarify the relationship with the sensitivity to gemcitabine. | gemcitabine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | The expression levels of ABCC5 were inversely correlated with gemcitabine sensitivity significantly (r = 0.628; P < 0.01) in 17 NSCLC cells, whereas the expression of ABCC5 in the gemcitabine-resistant NSCLC cell line H23/GEM-R was the same as that in parental NCI-H23 cells. | gemcitabine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | The expression levels of ABCC5 were inversely correlated with gemcitabine sensitivity significantly (r = 0.628; P < 0.01) in 17 NSCLC cells, whereas the expression of ABCC5 in the gemcitabine-resistant NSCLC cell line H23/GEM-R was the same as that in parental NCI-H23 cells. | gemcitabine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | Treatment with the ABCC5 inhibitor zaprinast altered the sensitivity to gemcitabine in ABCC5-expressing NSCLC cells. | zaprinast | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | Treatment with the ABCC5 inhibitor zaprinast altered the sensitivity to gemcitabine in ABCC5-expressing NSCLC cells. | zaprinast | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | Treatment with the ABCC5 inhibitor zaprinast altered the sensitivity to gemcitabine in ABCC5-expressing NSCLC cells. | gemcitabine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 8 | Treatment with the ABCC5 inhibitor zaprinast altered the sensitivity to gemcitabine in ABCC5-expressing NSCLC cells. | gemcitabine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 9 | In addition, decreasing the expression of ABCC5 by small interfering RNA altered the cytotoxicity to gemcitabine. | gemcitabine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 10 | These results indicate that modulation of ABCC5 activity could be used to increase the gemcitabine sensitivity in NSCLC. | gemcitabine | ATP binding cassette subfamily C member 5 | Homo sapiens |