Pub. Date : 2002 May
PMID : 11956491
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 8 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 9 | In addition to degradation by phosphodiesterase, cGMP is exported from cells by multidrug resistance protein 5 (MRP5), also called ABCC5, which we recently identified as an adenosine triphosphate dependent export pump for cGMP. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 10 | MRP5 is potently inhibited by substances known as phosphodiesterase inhibitors, including sildenafil and trequinsin. | Sildenafil Citrate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 11 | MRP5 is potently inhibited by substances known as phosphodiesterase inhibitors, including sildenafil and trequinsin. | trequinsin | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 12 | CONCLUSIONS: The co-expression of MRP5 and phosphodiesterase 5 in smooth muscle cells of the genitourinary system indicates 2 distinct pathways for cGMP removal. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 13 | Thus, MRP5 inhibition represents a new approach for enhancing cGMP levels in smooth muscle cells and developing drugs for erectile dysfunction. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |