Pub. Date : 2002 Dec
PMID : 12435799
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. | 2-mercaptopyrazine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | Overexpression of the two related multidrug resistance proteins MRP4 and MRP5 has been shown to confer some resistance against mercaptopurines, which has been attributed to extrusion of mercaptopurine metabolites by these transporters. | Mercaptopurine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | Overexpression of the two related multidrug resistance proteins MRP4 and MRP5 has been shown to confer some resistance against mercaptopurines, which has been attributed to extrusion of mercaptopurine metabolites by these transporters. | Mercaptopurine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | Incubation with 6MP led to the formation of thioinosine and thioxanthosine metabolites and we found that thio-IMP was transported by both MRP4 and MRP5; MRP5 showed the highest transport rate. | Mercaptopurine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | Incubation with 6MP led to the formation of thioinosine and thioxanthosine metabolites and we found that thio-IMP was transported by both MRP4 and MRP5; MRP5 showed the highest transport rate. | Mercaptopurine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | Incubation with 6MP led to the formation of thioinosine and thioxanthosine metabolites and we found that thio-IMP was transported by both MRP4 and MRP5; MRP5 showed the highest transport rate. | Thioinosine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | Incubation with 6MP led to the formation of thioinosine and thioxanthosine metabolites and we found that thio-IMP was transported by both MRP4 and MRP5; MRP5 showed the highest transport rate. | thioxanthosine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 8 | Incubation with 6MP led to the formation of thioinosine and thioxanthosine metabolites and we found that thio-IMP was transported by both MRP4 and MRP5; MRP5 showed the highest transport rate. | Thioinosinic acid | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 9 | Incubation with 6MP led to the formation of thioinosine and thioxanthosine metabolites and we found that thio-IMP was transported by both MRP4 and MRP5; MRP5 showed the highest transport rate. | Thioinosinic acid | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 10 | In contrast, only MRP5 transported thioxanthosine monophosphate (tXMP). | thioxanthosine monophosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 11 | In contrast, only MRP5 transported thioxanthosine monophosphate (tXMP). | 6-Thioxanthine 5'-monophosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 12 | During incubation with TG, the monophosphorylated form of thioguanosine was transported by both MRP4 and MRP5; the highest transport rate was for MRP4. | Thioguanine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 13 | During incubation with TG, the monophosphorylated form of thioguanosine was transported by both MRP4 and MRP5; the highest transport rate was for MRP4. | 6-thioguanosine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 14 | Our results show that all major thiopurine monophosphates important in the efficacy of mercaptopurine treatment are transported by MRP4 and MRP5, although the substrate specificity of the two transporters differs in detail. | thiopurine monophosphates | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 15 | Our results show that all major thiopurine monophosphates important in the efficacy of mercaptopurine treatment are transported by MRP4 and MRP5, although the substrate specificity of the two transporters differs in detail. | Mercaptopurine | ATP binding cassette subfamily C member 5 | Homo sapiens |