Title : Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?

Pub. Date : 2006 Jul 1

PMID : 16516478






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Opposite effects of flavonoid derivatives on the P-gp highly expressing and MDA-MB-435 non-expressing cell lines indicate that paclitaxel is not only transported by P-gp and let us assume that Mrp2 or ABCC5 seem to be good transport-candidates in these cells. Paclitaxel ATP binding cassette subfamily C member 5 Homo sapiens