Pub. Date : 2006 Apr
PMID : 16337112
20 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Nucleosides | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Nucleosides | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Nucleosides | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Platinum | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 8 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Platinum | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 9 | Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds. | Platinum | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 10 | In cellular assays, MRP5 transfectants are less fluorescent after incubation with 5-chloromethylfluorescein diacetate (CMFDA). | 5-chloromethylfluorescein | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 11 | In cellular assays, MRP5 transfectants are less fluorescent after incubation with 5-chloromethylfluorescein diacetate (CMFDA). | 5-chloromethylfluorescein | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 12 | MRP5-mediated uptake of CDCF was ATP-dependent and GSH-independent and possessed a Km of 12 microM and a Vmax of 56 pmol/min/mg prot. | 5-Carboxy-2',7'-dichlorofluorescein | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 13 | MRP5-mediated uptake of CDCF was ATP-dependent and GSH-independent and possessed a Km of 12 microM and a Vmax of 56 pmol/min/mg prot. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 14 | MRP5-mediated uptake of CDCF was ATP-dependent and GSH-independent and possessed a Km of 12 microM and a Vmax of 56 pmol/min/mg prot. | Glutathione | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 15 | In addition, the potency of MRP5 inhibitors such as probenecid, MK571, and the phosphodiesterase 5 inhibitors correlated well between the uptake of CDCF and MTX. | Probenecid | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 16 | In addition, the potency of MRP5 inhibitors such as probenecid, MK571, and the phosphodiesterase 5 inhibitors correlated well between the uptake of CDCF and MTX. | verlukast | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 17 | In addition, the potency of MRP5 inhibitors such as probenecid, MK571, and the phosphodiesterase 5 inhibitors correlated well between the uptake of CDCF and MTX. | 5-Carboxy-2',7'-dichlorofluorescein | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 18 | In addition, the potency of MRP5 inhibitors such as probenecid, MK571, and the phosphodiesterase 5 inhibitors correlated well between the uptake of CDCF and MTX. | Methotrexate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 19 | Taken together, these data indicate that CDCF is a useful fluorescent drug surrogate with which to measure ATP-dependent MRP5-mediated transport. | 5-Carboxy-2',7'-dichlorofluorescein | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 20 | Taken together, these data indicate that CDCF is a useful fluorescent drug surrogate with which to measure ATP-dependent MRP5-mediated transport. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |