Pub. Date : 2005 May
PMID : 15897250
20 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | The present study shows that the ATP-dependent multidrug resistance protein-5 (MRP5, ABCC5) confers resistance to 5-FU by transporting the monophosphate metabolites. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | The present study shows that the ATP-dependent multidrug resistance protein-5 (MRP5, ABCC5) confers resistance to 5-FU by transporting the monophosphate metabolites. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | The present study shows that the ATP-dependent multidrug resistance protein-5 (MRP5, ABCC5) confers resistance to 5-FU by transporting the monophosphate metabolites. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | The present study shows that the ATP-dependent multidrug resistance protein-5 (MRP5, ABCC5) confers resistance to 5-FU by transporting the monophosphate metabolites. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | The present study shows that the ATP-dependent multidrug resistance protein-5 (MRP5, ABCC5) confers resistance to 5-FU by transporting the monophosphate metabolites. | monophosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | The present study shows that the ATP-dependent multidrug resistance protein-5 (MRP5, ABCC5) confers resistance to 5-FU by transporting the monophosphate metabolites. | monophosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 8 | In 3-day cytotoxicity assays, MRP5-transfected cells were approximately 9-fold resistant to 5-FU and 6-thioguanine. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 9 | In 3-day cytotoxicity assays, MRP5-transfected cells were approximately 9-fold resistant to 5-FU and 6-thioguanine. | Thioguanine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 10 | Studies with inside-out membrane vesicles prepared from transfected cells showed that MRP5 mediates ATP-dependent transport of 5 micromol/L [(3)H]5-FdUMP, [(3)H]5-FUMP, [(3)H]dUMP, and not [(3)H]5-FUdR, or [(3)H]5-FU. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 11 | Studies with inside-out membrane vesicles prepared from transfected cells showed that MRP5 mediates ATP-dependent transport of 5 micromol/L [(3)H]5-FdUMP, [(3)H]5-FUMP, [(3)H]dUMP, and not [(3)H]5-FUdR, or [(3)H]5-FU. | 5-fdump | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 12 | Studies with inside-out membrane vesicles prepared from transfected cells showed that MRP5 mediates ATP-dependent transport of 5 micromol/L [(3)H]5-FdUMP, [(3)H]5-FUMP, [(3)H]dUMP, and not [(3)H]5-FUdR, or [(3)H]5-FU. | 5-fluorouridine 5'-phosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 13 | Studies with inside-out membrane vesicles prepared from transfected cells showed that MRP5 mediates ATP-dependent transport of 5 micromol/L [(3)H]5-FdUMP, [(3)H]5-FUMP, [(3)H]dUMP, and not [(3)H]5-FUdR, or [(3)H]5-FU. | 2'-deoxyuridylic acid | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 14 | Studies with inside-out membrane vesicles prepared from transfected cells showed that MRP5 mediates ATP-dependent transport of 5 micromol/L [(3)H]5-FdUMP, [(3)H]5-FUMP, [(3)H]dUMP, and not [(3)H]5-FUdR, or [(3)H]5-FU. | 5-fluoro-2'-deoxyuridine | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 15 | Studies with inside-out membrane vesicles prepared from transfected cells showed that MRP5 mediates ATP-dependent transport of 5 micromol/L [(3)H]5-FdUMP, [(3)H]5-FUMP, [(3)H]dUMP, and not [(3)H]5-FUdR, or [(3)H]5-FU. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 16 | Furthermore, the 5-FU drug sensitivity of HEK-MRP5 cells was partially modulated to that of the HEK-vector by the presence of 40 micromol/L 5-nitro-2-(3-phenylpropylamino)-benzoic acid but not by 2 mmol/L probenecid. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 17 | Furthermore, the 5-FU drug sensitivity of HEK-MRP5 cells was partially modulated to that of the HEK-vector by the presence of 40 micromol/L 5-nitro-2-(3-phenylpropylamino)-benzoic acid but not by 2 mmol/L probenecid. | 5-nitro-2-(3-phenylpropylamino)benzoic acid | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 18 | Furthermore, the 5-FU drug sensitivity of HEK-MRP5 cells was partially modulated to that of the HEK-vector by the presence of 40 micromol/L 5-nitro-2-(3-phenylpropylamino)-benzoic acid but not by 2 mmol/L probenecid. | Probenecid | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 19 | Thus, MRP5 transports the monophosphorylated metabolite of this nucleoside and when MRP5 is overexpressed in colorectal and breast tumors, it may contribute to 5-FU drug resistance. | Nucleosides | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 20 | Thus, MRP5 transports the monophosphorylated metabolite of this nucleoside and when MRP5 is overexpressed in colorectal and breast tumors, it may contribute to 5-FU drug resistance. | Nucleosides | ATP binding cassette subfamily C member 5 | Homo sapiens |