Pub. Date : 2008 Aug
PMID : 18690847
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the study was to investigate the induction by celecoxib of some multidrug resistance proteins, MRP1, MRP2, MRP4 and MRP5, involved in the transport of irinotecan and 5-FU. | Celecoxib | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | The aim of the study was to investigate the induction by celecoxib of some multidrug resistance proteins, MRP1, MRP2, MRP4 and MRP5, involved in the transport of irinotecan and 5-FU. | Irinotecan | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | The aim of the study was to investigate the induction by celecoxib of some multidrug resistance proteins, MRP1, MRP2, MRP4 and MRP5, involved in the transport of irinotecan and 5-FU. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | In both cell lines celecoxib induced MRP4 and MRP5 over-expression at RNA and protein levels. | Celecoxib | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | Cryoimmunoelectron microscopy showed increased MRP4 and MRP5 immunolabeling in celecoxib treated cells both at cytoplasmic level and along the plasma membrane. | Celecoxib | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | Our findings, together with the results of clinical trials, may suggest that the combined use of celecoxib and drugs that are substrate for MRP4/MRP5 should be avoided. | Celecoxib | ATP binding cassette subfamily C member 5 | Homo sapiens |