Pub. Date : 2007 Sep 6
PMID : 17803828
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: In order to elucidate structural and molecular concepts of multidrug resistance, we have constructed a molecular model of the ATP-bound outward facing conformation of the human multidrug resistance protein ABCB1 using the Sav1866 crystal structure as a template, and compared the ABCB1 model with a previous ABCC5 model. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | In contrast, EPS of the ABCC5 substrate translocation chamber, which transports organic anions, was generally positive. | eps | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | The EPS in the substrate translocation chambers and the positive-negative ratio of charged amino acids were in accordance with the transport of cationic amphiphilic and lipophilic substrates by ABCB1, and the transport of organic anions by ABCC5. | eps | ATP binding cassette subfamily C member 5 | Homo sapiens |