Pub. Date : 2009
PMID : 19077464
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compared to parental Capan-1 cells, Capan-1 cells with acquired chemoresistance towards 5-fluorouracil showed an upregulated mRNA and protein expression of MRP3, MRP4, and MRP5. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | In addition, silencing of MRP5 by RNA interference resulted in enhanced sensitivity of parental Capan-1 cells towards 5-fluorouracil cytotoxicity. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | CONCLUSION: MRP3, MRP4, and MRP5 are upregulated in 5-fluorouracil-resistant cells, and MRP5 contributes to 5-FU resistance in pancreatic carcinoma cells. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | CONCLUSION: MRP3, MRP4, and MRP5 are upregulated in 5-fluorouracil-resistant cells, and MRP5 contributes to 5-FU resistance in pancreatic carcinoma cells. | Fluorouracil | ATP binding cassette subfamily C member 5 | Homo sapiens |