Pub. Date : 2000 Sep 29
PMID : 10893247
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATP-dependent transport of 3",5"-cyclic GMP at a substrate concentration of 1 micrometer was 4-fold higher in membrane vesicles from MRP5-transfected cells than in control membranes. | Adenosine Triphosphate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | ATP-dependent transport of 3",5"-cyclic GMP at a substrate concentration of 1 micrometer was 4-fold higher in membrane vesicles from MRP5-transfected cells than in control membranes. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 3 | MRP5-mediated transport was also detected for 3",5"-cyclic AMP at a lower affinity, with a K(m) value of 379 micrometer. | Cyclic AMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 4 | A potent inhibition of MRP5-mediated transport was observed by several compounds, known as phosphodiesterase modulators, including trequinsin, with a K(i) of 240 nm, and sildenafil, with a K(i) value of 267 nm. | trequinsin | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 5 | A potent inhibition of MRP5-mediated transport was observed by several compounds, known as phosphodiesterase modulators, including trequinsin, with a K(i) of 240 nm, and sildenafil, with a K(i) value of 267 nm. | Sildenafil Citrate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 6 | Thus, cyclic nucleotides are physiological substrates for MRP5; moreover, MRP5 may represent a novel pharmacological target for the enhancement of tissue levels of cGMP. | Nucleotides, Cyclic | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 7 | Thus, cyclic nucleotides are physiological substrates for MRP5; moreover, MRP5 may represent a novel pharmacological target for the enhancement of tissue levels of cGMP. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 8 | Thus, cyclic nucleotides are physiological substrates for MRP5; moreover, MRP5 may represent a novel pharmacological target for the enhancement of tissue levels of cGMP. | Cyclic GMP | ATP binding cassette subfamily C member 5 | Homo sapiens |