| 1 |
35366770 | Insights into Interactions of Human Cytochrome P450 17A1: Review. | 2022 Apr 1 |
1 |
| 2 |
33656879 | Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5. | 2021 Mar 17 |
1 |
| 3 |
34662099 | Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1. | 2021 Nov 2 |
2 |
| 4 |
32554434 | Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen. | 2020 Sep |
1 |
| 5 |
32681807 | P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency. | 2020 Dec 15 |
2 |
| 6 |
30022431 | Dehydroepiandrosterone Induces Temozolomide Resistance Through Modulating Phosphorylation and Acetylation of Sp1 in Glioblastoma. | 2019 Apr |
2 |
| 7 |
30896833 | Expression of steroidogenic enzymes in human placenta according to the gestational age. | 2019 May |
2 |
| 8 |
31031706 | The Effect of Soy Isoflavones on Steroid Metabolism. | 2019 |
2 |
| 9 |
31509771 | Effect of mutations in porcine CYB5A and CYP17A1 on the metabolism of pregnenolone. | 2019 Dec |
5 |
| 10 |
31767173 | Steroidogenic control of liver metabolism through a nuclear receptor-network. | 2019 Dec |
1 |
| 11 |
31933595 | CYP17A1 and Androgen-Receptor Expression in Prostate Carcinoma Tissues and Cancer Cell Lines. | 2019 Nov |
1 |
| 12 |
29283561 | Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202. | 2018 Feb 6 |
1 |
| 13 |
29710837 | Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency. | 2018 Apr 29 |
1 |
| 14 |
30029732 | Dehydroepiandrosterone (DHEA)-SO4 Depot and Castration-Resistant Prostate Cancer. | 2018 |
4 |
| 15 |
30229581 | Functional Identification of Compound Heterozygous Mutations in the CYP17A1 Gene Resulting in Combined 17α-Hydroxylase/17,20-Lyase Deficiency. | 2018 Sep |
1 |
| 16 |
27702589 | Electrochemistry of cytochrome P450 17α-hydroxylase/17,20-lyase (P450c17). | 2017 Feb 5 |
2 |
| 17 |
28530704 | Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma. | 2017 May 22 |
8 |
| 18 |
28684414 | Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. | 2017 Aug 11 |
2 |
| 19 |
28707358 | Suppressed oligodendrocyte steroidogenesis in multiple sclerosis: Implications for regulation of neuroinflammation. | 2017 Oct |
2 |
| 20 |
28890368 | CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. | 2017 Nov |
1 |
| 21 |
27748439 | Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer. | 2016 Oct 17 |
2 |
| 22 |
27798284 | Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults. | 2016 Dec |
1 |
| 23 |
25514466 | The DHEA-sulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer. | 2015 Jun 5 |
1 |
| 24 |
26668369 | Unveiling the crucial intermediates in androgen production. | 2015 Dec 29 |
2 |
| 25 |
24389397 | Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia. | 2014 Apr 3 |
4 |
| 26 |
23415678 | The relevance of chemical interactions with CYP17 enzyme activity: assessment using a novel in vitro assay. | 2013 May 1 |
4 |
| 27 |
23470964 | Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer. | 2013 Jul 1 |
1 |
| 28 |
23770321 | Assessment of steroidogenesis and steroidogenic enzyme functions. | 2013 Sep |
1 |
| 29 |
23775394 | Association between a common CYP17A1 haplotype and anxiety in female anorexia nervosa. | 2013 Oct |
1 |
| 30 |
24160919 | Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate. | 2013 Nov 6 |
1 |
| 31 |
24314739 | [CYP17A1 inhibitors in prostate cancer: mechanisms of action independent of the androgenic pathway]. | 2013 Oct |
1 |
| 32 |
22024430 | Variation in 3β-hydroxysteroid dehydrogenase activity and in pregnenolone supply rate can paradoxically alter androstenedione synthesis. | 2012 Jan |
2 |
| 33 |
22649409 | Dehydroepiandrosterone biosynthesis, role, and mechanism of action in the developing neural tube. | 2012 |
2 |
| 34 |
21335661 | A lead study on oxidative stress-mediated dehydroepiandrosterone formation in serum: the biochemical basis for a diagnosis of Alzheimer's disease. | 2011 |
2 |
| 35 |
21541365 | Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. | 2011 Apr |
2 |
| 36 |
21868758 | Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. | 2011 Oct 15 |
2 |
| 37 |
22654823 | Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer's Disease Diagnosis. | 2011 |
1 |
| 38 |
18821018 | Androgen synthesis in adrenarche. | 2009 Mar |
1 |
| 39 |
19474057 | Plasticity of the zona reticularis in the adult marmoset adrenal cortex: voyages of discovery in the New World. | 2009 Dec |
2 |
| 40 |
19497978 | The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production. | 2009 Sep |
2 |
| 41 |
18493130 | Steroidogenic enzymes. | 2008 |
1 |
| 42 |
18493132 | Adrenal androgens in humans and nonhuman primates: production, zonation and regulation. | 2008 |
1 |
| 43 |
16971197 | CYP17 and COMT gene polymorphisms can influence bone directly, or indirectly through their effects on endogenous sex steroids, in postmenopausal Japanese women. | 2007 Jan |
2 |
| 44 |
17326004 | Sexual hormones in human skin. | 2007 Feb |
1 |
| 45 |
16828825 | In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action? | 2006 Oct 15 |
4 |
| 46 |
16103714 | Disorders of androgen synthesis--from cholesterol to dehydroepiandrosterone. | 2005 |
1 |
| 47 |
31627556 | [Dehydroepiandrosterone: physiological role and possibilities of use as a drug]. | 2005 Apr 15 |
2 |
| 48 |
15635496 | Overview of dehydroepiandrosterone biosynthesis. | 2004 Nov |
1 |
| 49 |
12464253 | Ovine steroid 17alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme. | 2003 Jan 1 |
1 |
| 50 |
12573489 | Molecular dynamics of substrate complexes with hamster cytochrome P450c17 (CYP17): mechanistic approach to understanding substrate binding and activities. | 2003 Feb 17 |
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