Title : Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer.

Pub. Date : 2016 Oct 17

PMID : 27748439






2 Functional Relationships(s)
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1 Administration of VT-464 in a metastatic CRPC patient presenting with high tumoral expression of both androgen receptor (AR) and CYP17A1, showed significant reduction in the level of both dehydroepiandrosterone (DHEA) and serum PSA. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Administration of VT-464 in a metastatic CRPC patient presenting with high tumoral expression of both androgen receptor (AR) and CYP17A1, showed significant reduction in the level of both dehydroepiandrosterone (DHEA) and serum PSA. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens