Pub. Date : 2006 Oct 15
PMID : 16828825
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP17 enzyme catalyzes an important step in sex steroidogenesis and is responsible for the biosynthesis of dehydroepiandrosterone (DHEA) and androstenedione in the adrenals. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | CYP17 enzyme catalyzes an important step in sex steroidogenesis and is responsible for the biosynthesis of dehydroepiandrosterone (DHEA) and androstenedione in the adrenals. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | The precursor substrate of CYP17, pregnenolone, was added to control and exposed H295R cells, and enzymatic production of DHEA was measured using a radioimmunoassay. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | Replacement of the 6-OH group by a 6-CH(3)O group eliminated this cytotoxic effect, but CYP17 activity measured as DHEA production was still significantly inhibited. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |