Title : CYP17 and COMT gene polymorphisms can influence bone directly, or indirectly through their effects on endogenous sex steroids, in postmenopausal Japanese women.

Pub. Date : 2007 Jan

PMID : 16971197






2 Functional Relationships(s)
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1 On the total cohort, a difference in endogenous DHEA levels between CYP17 homozygote A2 and non-homozygote A2; an increasing trend in AND levels from COMT L/L, L/H, to H/H; and a difference in TS level between COMT homozygote L and non-homozygote L were separately observed. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 In thin/normal-weight women (BMI <25 kg/m2), the same effects of CYP17 genotypes on DHEA were observed as on the total cohort. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens