Pub. Date : 2017 May 22
PMID : 28530704
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 5 | Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 6 | However, whether CYP17A1-mediated DHEA synthesis is involved in brain tumor malignancy, especially in glioma, the most prevalent brain tumor, is unknown. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 7 | To investigate the role of CYP17A1 in glioma, we determined that CYP17A1 expression is significantly increased in gliomas, which secrete more DHEA than normal astrocytes. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 8 | Together, our results suggest that components of the Sp1-CYP17A1-DHEA axis, which promotes the development of TMZ resistance, may serve as potential biomarkers and therapeutic targets in recurrent glioma. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |