Title : Steroidogenic control of liver metabolism through a nuclear receptor-network.

Pub. Date : 2019 Dec

PMID : 31767173






1 Functional Relationships(s)
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1 Both gain- and loss-of-function approaches are used to show that hepatic Cyp17a1 is induced by fasting, catalyzes the production of at least one hormone-ligand (DHEA) for the nuclear receptor PPARalpha, and is ultimately required for maintaining euglycemia and ketogenesis during nutrient deprivation. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens