PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9933021-2 1999 Molecular O2 is an obligatory substrate for the successive syntheses of 17alpha-OH pregnenolone and dehydroepiandrosterone (DHEA) by cytochrome P450c17 in the zona reticularis of the adrenal cortex, in which it is suggested that arteriosclerosis --> decreased blood flow --> O2 and glucose deficit --> decreased O2-requiring synthesis of DHEA --> eventual decrease in number of DHEA-synthesizing cells. Dehydroepiandrosterone 100-122 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 144-151 9933021-2 1999 Molecular O2 is an obligatory substrate for the successive syntheses of 17alpha-OH pregnenolone and dehydroepiandrosterone (DHEA) by cytochrome P450c17 in the zona reticularis of the adrenal cortex, in which it is suggested that arteriosclerosis --> decreased blood flow --> O2 and glucose deficit --> decreased O2-requiring synthesis of DHEA --> eventual decrease in number of DHEA-synthesizing cells. Dehydroepiandrosterone 124-128 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 144-151 9933021-2 1999 Molecular O2 is an obligatory substrate for the successive syntheses of 17alpha-OH pregnenolone and dehydroepiandrosterone (DHEA) by cytochrome P450c17 in the zona reticularis of the adrenal cortex, in which it is suggested that arteriosclerosis --> decreased blood flow --> O2 and glucose deficit --> decreased O2-requiring synthesis of DHEA --> eventual decrease in number of DHEA-synthesizing cells. Dehydroepiandrosterone 347-351 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 144-151 9933021-2 1999 Molecular O2 is an obligatory substrate for the successive syntheses of 17alpha-OH pregnenolone and dehydroepiandrosterone (DHEA) by cytochrome P450c17 in the zona reticularis of the adrenal cortex, in which it is suggested that arteriosclerosis --> decreased blood flow --> O2 and glucose deficit --> decreased O2-requiring synthesis of DHEA --> eventual decrease in number of DHEA-synthesizing cells. Dehydroepiandrosterone 347-351 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 144-151 9927319-5 1999 The presence of P450c17 in astrocytes and neurons was supported by the ability of these cells to metabolize pregnenolone to DHEA in a dose-dependent manner as determined by RIA. Dehydroepiandrosterone 124-128 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 16-23 9927319-14 1999 These data suggest that as in gonads and adrenal, DHEA is biosynthesized in the brain by a P450c17-dependent mechanism. Dehydroepiandrosterone 50-54 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 91-98 9768686-4 1998 After conversion of cholesterol to pregnenolone, 17alpha-hydroxylase/17,20-lyase (CYP17) can metabolize pregnenolone through to DHEA. Dehydroepiandrosterone 128-132 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 82-87 9768686-5 1998 The enzyme 3betaHSD competes for substrate with CYP17 and effectively removes steroid precursor from the pathway leading to DHEA. Dehydroepiandrosterone 124-128 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 48-53 34662099-7 2021 For example, the replacement of the glutamic acid side with a glycine chain at position 305 in the CYP17A1 structure causes a clinically relevant steroidopathy; E305G CYP17A1 displays a dramatic decrease in the production of dehydroepiandrosterone from pregnenolone but surprisingly increases the activity of the enzyme toward the formation of androstenedione from progesterone. Dehydroepiandrosterone 225-247 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 99-106 9888582-1 1998 Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. Dehydroepiandrosterone 252-256 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 6-13 9888582-1 1998 Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. Dehydroepiandrosterone 252-256 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 144-151 9888582-2 1998 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. Dehydroepiandrosterone 284-288 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 19-26 9888582-2 1998 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. Dehydroepiandrosterone 284-288 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 152-159 9539798-2 1998 DHEA and DHEAS are found in brains from many species, and we have shown that enzymes crucial for their synthesis, especially P450c17 (17alpha-hydroxylase/c17,20 lyase), are expressed in a developmentally regulated, region-specific fashion in the developing rodent brain. Dehydroepiandrosterone 0-4 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 125-132 9890062-8 1998 Finally, 17-OH pregnenolone is converted to DHEA by the 17,20 lyase activity of P450c17. Dehydroepiandrosterone 44-48 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 80-87 9890062-9 1998 Isolated 17,20 lyase deficiency is rare, but the identification of its genetic basis and the study of P450c17 enzymology have recently clarified the mechanisms by which DHEA synthesis may be regulated in adrenarche, and have suggested that the lesion underlying polycystic ovary syndrome might involve a serine kinase. Dehydroepiandrosterone 169-173 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 102-109 9467556-12 1998 In conclusion, the present study demonstrated a potent inhibitory effect of CRF on LH-stimulated dehydroepiandrosterone and androstenedione production that appears to be mediated through the reduction of P450c17 gene expression. Dehydroepiandrosterone 97-119 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 204-211 34662099-7 2021 For example, the replacement of the glutamic acid side with a glycine chain at position 305 in the CYP17A1 structure causes a clinically relevant steroidopathy; E305G CYP17A1 displays a dramatic decrease in the production of dehydroepiandrosterone from pregnenolone but surprisingly increases the activity of the enzyme toward the formation of androstenedione from progesterone. Dehydroepiandrosterone 225-247 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 167-174 33656879-1 2021 CYP17A1 is an essential human steroidogenic enzyme, which catalyzes two sequential reactions leading to the formation of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone. Dehydroepiandrosterone 159-181 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 35366770-5 2022 This P450c17 cytochrome gene is a critical steroidogenesis regulator which performs two distinct activities: 17 alpha-hydroxylase activity (converting pregnenolone to 17-hydroxypregnenolone and progesterone to 17-hydroxyprogesterone, these precursors are further processed to provide glucocorticoids and sex hormones) and 17, 20-lyase activity (which converts 17-hydroxypregnenolone to DHEA). Dehydroepiandrosterone 386-390 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 5-12 32554434-5 2020 Prolonged suppression of dehydroepiandrosterone (DHEA) concentrations observed in VCaP cells after abiraterone washout corroborated its protracted CYP17A1 engagement. Dehydroepiandrosterone 49-53 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 147-154 32681807-1 2020 Human cytochrome P450 CYP17A1 first catalyzes hydroxylation at the C17 position of either PREG or PROG, and a subsequent C 17 -C 20 bond scission to produce dehydroepiandrosterone ( DHEA) or androstenedione (AD). Dehydroepiandrosterone 157-179 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 32681807-1 2020 Human cytochrome P450 CYP17A1 first catalyzes hydroxylation at the C17 position of either PREG or PROG, and a subsequent C 17 -C 20 bond scission to produce dehydroepiandrosterone ( DHEA) or androstenedione (AD). Dehydroepiandrosterone 182-186 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 30896833-7 2019 The mRNA and protein expression of CYP17A1, HSD17B3 and CYP19A1, which are associated with the synthesis of dehydroepiandrosterone (DHEA) and E2, was elevated at different gestational ages in human placenta. Dehydroepiandrosterone 132-136 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 35-42 31509771-1 2019 Cytochrome P450 17A1 (CYP17A1) catalyses the 17alpha-hydroxylation and 17,20 lyase reactions to convert pregnenolone to 17alpha-hydroxypregnenolone (17OHP) and subsequently the androgen dehydroepiandrosterone (DHEA). Dehydroepiandrosterone 186-208 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 31509771-1 2019 Cytochrome P450 17A1 (CYP17A1) catalyses the 17alpha-hydroxylation and 17,20 lyase reactions to convert pregnenolone to 17alpha-hydroxypregnenolone (17OHP) and subsequently the androgen dehydroepiandrosterone (DHEA). Dehydroepiandrosterone 186-208 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 31509771-1 2019 Cytochrome P450 17A1 (CYP17A1) catalyses the 17alpha-hydroxylation and 17,20 lyase reactions to convert pregnenolone to 17alpha-hydroxypregnenolone (17OHP) and subsequently the androgen dehydroepiandrosterone (DHEA). Dehydroepiandrosterone 210-214 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 31509771-1 2019 Cytochrome P450 17A1 (CYP17A1) catalyses the 17alpha-hydroxylation and 17,20 lyase reactions to convert pregnenolone to 17alpha-hydroxypregnenolone (17OHP) and subsequently the androgen dehydroepiandrosterone (DHEA). Dehydroepiandrosterone 210-214 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 31509771-4 2019 We have identified and mutated residues in porcine CYP17A1 and CYB5A that may alter the synthesis of DHEA and 16A. Dehydroepiandrosterone 101-105 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 51-58 31933595-1 2019 Background: CYP17A1 is involved in the steroidogenesis of dehydroepiandrosterone and androstenedione. Dehydroepiandrosterone 58-80 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 12-19 30896833-7 2019 The mRNA and protein expression of CYP17A1, HSD17B3 and CYP19A1, which are associated with the synthesis of dehydroepiandrosterone (DHEA) and E2, was elevated at different gestational ages in human placenta. Dehydroepiandrosterone 108-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 35-42 31767173-4 2019 Both gain- and loss-of-function approaches are used to show that hepatic Cyp17a1 is induced by fasting, catalyzes the production of at least one hormone-ligand (DHEA) for the nuclear receptor PPARalpha, and is ultimately required for maintaining euglycemia and ketogenesis during nutrient deprivation. Dehydroepiandrosterone 161-165 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 73-80 31031706-3 2019 We focused on cytochrome P450 17alpha-hydroxylase (CYP17A1) which catalyses the production of dehydroepiandrosterone (DHEA), in the androgen biosynthesis pathway to elucidate effects on sex steroids in vitro. Dehydroepiandrosterone 94-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 51-58 31031706-3 2019 We focused on cytochrome P450 17alpha-hydroxylase (CYP17A1) which catalyses the production of dehydroepiandrosterone (DHEA), in the androgen biosynthesis pathway to elucidate effects on sex steroids in vitro. Dehydroepiandrosterone 118-122 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 51-58 30022431-4 2019 Previously, we determined that aberrantly activated cytochrome P450 17A1 causes TMZ resistance in MGMT-deficient glioblastoma by increasing the secretion of dehydroepiandrosterone (DHEA), a neurosteroid that maintains the health of neurons and astrocytes. Dehydroepiandrosterone 157-179 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-72 30022431-4 2019 Previously, we determined that aberrantly activated cytochrome P450 17A1 causes TMZ resistance in MGMT-deficient glioblastoma by increasing the secretion of dehydroepiandrosterone (DHEA), a neurosteroid that maintains the health of neurons and astrocytes. Dehydroepiandrosterone 181-185 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-72 30229581-6 2018 And the activities of 17alpha-hydroxylase and 17,20-lyase of CYP17A1 were evaluated by measuring the conversion of progesterone to 17alpha-hydroxyprogesterone and of 17alpha-hydroxypregnenolone to dehydroepiandrosterone, respectively. Dehydroepiandrosterone 197-219 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 61-68 25514466-10 2015 We therefore present the case that in the context of the DHEA-S depot, P450c17 and AKR1C3 inhibition may be an effective combinatorial treatment strategy. Dehydroepiandrosterone 57-63 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 71-78 29283561-5 2018 Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. Dehydroepiandrosterone 225-247 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 80-87 28890368-7 2017 In addition, co-administration of Abi abrogated pregnenolone metabolism and resulted in a CYP17A1-independent significant increase of DHEA (13- to >100-fold) and DHT (2.5-fold) in androgen-responsive cells. Dehydroepiandrosterone 134-138 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 90-97 28707358-4 2017 CNS tissues from patients with MS and animals with experimental autoimmune encephalomyelitis (EAE) displayed reduced DHEA concentrations, accompanied by diminished expression of the DHEA-synthesizing enzyme CYP17A1 in oligodendrocytes (ODCs), in association with increased expression of inflammatory genes including interferon (IFN)-gamma and interleukin (IL)-1beta. Dehydroepiandrosterone 182-186 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 207-214 28707358-10 2017 Thus, CYP17A1 expression in ODCs and its product DHEA were downregulated in the CNS during inflammatory demyelination while DHEA-S provision suppressed neuroinflammation, demyelination, and axonal injury that was evident as improved neurobehavioral performance. Dehydroepiandrosterone 49-53 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 6-13 28684414-1 2017 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens. Dehydroepiandrosterone 207-229 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-32 28684414-1 2017 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens. Dehydroepiandrosterone 231-235 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-32 28530704-0 2017 Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma. Dehydroepiandrosterone 98-102 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 16-23 28530704-2 2017 Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. Dehydroepiandrosterone 63-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 28530704-2 2017 Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. Dehydroepiandrosterone 63-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 28530704-2 2017 Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. Dehydroepiandrosterone 87-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 28530704-2 2017 Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. Dehydroepiandrosterone 87-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 28530704-3 2017 However, whether CYP17A1-mediated DHEA synthesis is involved in brain tumor malignancy, especially in glioma, the most prevalent brain tumor, is unknown. Dehydroepiandrosterone 34-38 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 17-24 28530704-4 2017 To investigate the role of CYP17A1 in glioma, we determined that CYP17A1 expression is significantly increased in gliomas, which secrete more DHEA than normal astrocytes. Dehydroepiandrosterone 142-146 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 65-72 28530704-9 2017 Together, our results suggest that components of the Sp1-CYP17A1-DHEA axis, which promotes the development of TMZ resistance, may serve as potential biomarkers and therapeutic targets in recurrent glioma. Dehydroepiandrosterone 65-69 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 57-64 27748439-5 2016 Administration of VT-464 in a metastatic CRPC patient presenting with high tumoral expression of both androgen receptor (AR) and CYP17A1, showed significant reduction in the level of both dehydroepiandrosterone (DHEA) and serum PSA. Dehydroepiandrosterone 188-210 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 129-136 27748439-5 2016 Administration of VT-464 in a metastatic CRPC patient presenting with high tumoral expression of both androgen receptor (AR) and CYP17A1, showed significant reduction in the level of both dehydroepiandrosterone (DHEA) and serum PSA. Dehydroepiandrosterone 212-216 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 129-136 29710837-5 2018 Molecular dynamics (MD) simulations showed that V366M creates a &ldquo;one-way valve&rdquo; and suggests a mechanism for dual activities of human CYP17A1 where, after the conversion of pregnenolone to 17OH-pregnenolone, the product exits the active site and re-enters for conversion to dehydroepiandrosterone. Dehydroepiandrosterone 294-316 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 154-161 30029732-3 2018 DHEA is a product of the P450c17 (17alpha-hydroxylase-17,20-lyase) enzyme. Dehydroepiandrosterone 0-4 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 25-32 30029732-6 2018 The depot of DHEA-SO4 that remains after P450c17 inhibition and the adaptive responses that occur within the tumor to promote DHEA utilization contribute to mechanisms of drug resistance observed with P450c17 inhibitors. Dehydroepiandrosterone 13-17 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 41-48 30029732-6 2018 The depot of DHEA-SO4 that remains after P450c17 inhibition and the adaptive responses that occur within the tumor to promote DHEA utilization contribute to mechanisms of drug resistance observed with P450c17 inhibitors. Dehydroepiandrosterone 13-17 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 201-208 30029732-6 2018 The depot of DHEA-SO4 that remains after P450c17 inhibition and the adaptive responses that occur within the tumor to promote DHEA utilization contribute to mechanisms of drug resistance observed with P450c17 inhibitors. Dehydroepiandrosterone 126-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 201-208 27702589-3 2017 Cytochrome P450c17 is one of these and is also a multi-functional P450, with two activities, the first 17alpha-hydroxylation of pregnenolone is followed by a subsequent 17,20-lyase transformation to dehydroepiandrosterone (DHEA) as the dominant pathways to cortisol precursors or androgens in humans, respectively. Dehydroepiandrosterone 199-221 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 27702589-3 2017 Cytochrome P450c17 is one of these and is also a multi-functional P450, with two activities, the first 17alpha-hydroxylation of pregnenolone is followed by a subsequent 17,20-lyase transformation to dehydroepiandrosterone (DHEA) as the dominant pathways to cortisol precursors or androgens in humans, respectively. Dehydroepiandrosterone 223-227 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 27798284-5 2016 Genes related to glucolipid metabolism such as Ppargamma, Acot1/2, Fgf21, Pdk4 and Inhbb were upregulated in the liver of the offspring in DHEA group compared with those in controls, whereas Cyp17a1 expression was significantly decreased. Dehydroepiandrosterone 139-143 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 191-198 26668369-2 2015 The multifunctional cytochrome P450 17A1 (CYP17A1) first catalyzes the typical hydroxylation of its primary substrate, pregnenolone (PREG) and then also orchestrates a remarkable C17-C20 bond cleavage (lyase) reaction, converting the 17-hydroxypregnenolone initial product to dehydroepiandrosterone, a process representing the first committed step in the biosynthesis of androgens. Dehydroepiandrosterone 276-298 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-40 26668369-2 2015 The multifunctional cytochrome P450 17A1 (CYP17A1) first catalyzes the typical hydroxylation of its primary substrate, pregnenolone (PREG) and then also orchestrates a remarkable C17-C20 bond cleavage (lyase) reaction, converting the 17-hydroxypregnenolone initial product to dehydroepiandrosterone, a process representing the first committed step in the biosynthesis of androgens. Dehydroepiandrosterone 276-298 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 42-49 23775394-2 2013 We studied genetic variability in the DHEA-producing enzyme CYP17A1 in relation to anorexia nervosa (AN) susceptibility and AN-related co-morbidities. Dehydroepiandrosterone 38-42 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 60-67 24389397-3 2014 The biosynthesis of DHEA depends upon the activity of cytochrome P450c17alpha (CYP17). Dehydroepiandrosterone 20-24 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 54-77 24389397-3 2014 The biosynthesis of DHEA depends upon the activity of cytochrome P450c17alpha (CYP17). Dehydroepiandrosterone 20-24 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 79-84 24389397-5 2014 OBJECTIVE: To test the hypothesis that carriership of a more active CYP17 variant would result in higher DHEA(S) levels and protect against neurotoxicity which results in orofaciolingual TD (TDof), limb-truncal TD (TDlt) or both (TDsum). Dehydroepiandrosterone 105-109 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 68-73 24389397-9 2014 Conversely, carriers of the CYP17 T-allele have significant elevated DHEAS levels. Dehydroepiandrosterone 69-74 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 28-33 24160919-2 2013 In the formation of the male hormone dehydroepiandrosterone, pregnenolone is first hydroxylated by P450 CYP17A1 at the 17-carbon, followed a second round of catalysis by the same enzyme that cleaves the C17-C20 bond, releasing acetic acid and the 17-keto product. Dehydroepiandrosterone 37-59 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 104-111 23470964-3 2013 CYP17A1 catalyzes two essential reactions in the production of DHEA and androstenedione: the hydroxylation (hydroxylase activity) and the subsequent cleavage of the C17-20 side chain (lyase activity). Dehydroepiandrosterone 63-67 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 24314739-3 2013 RESULTS: Inhibition of CYP17A1 with abiraterone acetate induces changes in steroid metabolism, whose main component is the reduction of DHEA and androstenedione synthesis. Dehydroepiandrosterone 136-140 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 23-30 23770321-4 2013 The role of 17alpha-hydroxylase/17-20 lyase (CYP17A1) in the production of dehydroepiandrosterone and back-door pathways of dihydrotestosterone biosynthesis is also analyzed. Dehydroepiandrosterone 75-97 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-52 22649409-1 2012 Dehydroepiandrosterone (DHEA) is synthesized from cholesterol by activity of P450scc and P450c17, enzymes that we previously characterized in the developing nervous system. Dehydroepiandrosterone 0-22 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 89-96 23415678-1 2013 The steroidogenic cytochrome P450 17 (CYP17) enzyme produces dehydroepiandrosterone (DHEA), which is the most abundant circulating endogenous sex steroid precursor. Dehydroepiandrosterone 61-83 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 18-36 23415678-1 2013 The steroidogenic cytochrome P450 17 (CYP17) enzyme produces dehydroepiandrosterone (DHEA), which is the most abundant circulating endogenous sex steroid precursor. Dehydroepiandrosterone 61-83 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 38-43 23415678-1 2013 The steroidogenic cytochrome P450 17 (CYP17) enzyme produces dehydroepiandrosterone (DHEA), which is the most abundant circulating endogenous sex steroid precursor. Dehydroepiandrosterone 85-89 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 18-36 23415678-1 2013 The steroidogenic cytochrome P450 17 (CYP17) enzyme produces dehydroepiandrosterone (DHEA), which is the most abundant circulating endogenous sex steroid precursor. Dehydroepiandrosterone 85-89 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 38-43 22649409-1 2012 Dehydroepiandrosterone (DHEA) is synthesized from cholesterol by activity of P450scc and P450c17, enzymes that we previously characterized in the developing nervous system. Dehydroepiandrosterone 24-28 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 89-96 21868758-3 2011 DHEA and androstenedione are synthesized by the adrenals through the sequential actions of the cytochrome P450 enzymes CYP11A1 and CYP17A1, so that CYP17A1 inhibitors such as abiraterone are effective therapies for CRPC. Dehydroepiandrosterone 0-4 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 131-138 22654823-4 2011 Over the years we have reported that, unlike other neurosteroids, DHEA biosynthesis in rat, bovine, and human brain is mediated by an oxidative stress-mediated mechanism, independent of the cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17A1) enzyme activity found in the periphery. Dehydroepiandrosterone 66-70 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 239-246 22024430-6 2012 In these species, P450c17 has negligible 17,20-lyase activity with the Delta(4)-steroid 17alpha-hydroxy-progesterone (17OH-P4); therefore androstenedione (A4) is synthesized efficiently only from dehydroepiandrosterone (DHEA) through the Delta(5) pathway. Dehydroepiandrosterone 196-218 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 18-25 22024430-6 2012 In these species, P450c17 has negligible 17,20-lyase activity with the Delta(4)-steroid 17alpha-hydroxy-progesterone (17OH-P4); therefore androstenedione (A4) is synthesized efficiently only from dehydroepiandrosterone (DHEA) through the Delta(5) pathway. Dehydroepiandrosterone 220-224 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 18-25 21868758-3 2011 DHEA and androstenedione are synthesized by the adrenals through the sequential actions of the cytochrome P450 enzymes CYP11A1 and CYP17A1, so that CYP17A1 inhibitors such as abiraterone are effective therapies for CRPC. Dehydroepiandrosterone 0-4 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 148-155 21541365-3 2011 Phylogenetic findings on the evolution of neurotrophins, their receptors, and CYP17, the enzyme responsible for DHEA biosynthesis, combined with our data support the hypothesis that DHEA served as a phylogenetically ancient neurotrophic factor. Dehydroepiandrosterone 112-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 78-83 21541365-3 2011 Phylogenetic findings on the evolution of neurotrophins, their receptors, and CYP17, the enzyme responsible for DHEA biosynthesis, combined with our data support the hypothesis that DHEA served as a phylogenetically ancient neurotrophic factor. Dehydroepiandrosterone 182-186 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 78-83 17326004-3 2007 Sebocytes express very little of the key enzyme, cytochrome P450c17, necessary for synthesis of the androgenic prohormones dehydroepiandrosterone and androstenedione, however, these prohormones can be converted by sebocytes and sweat glands, and probably also by dermal papilla cells, into more potent androgens like testosterone and dihydrotestosterone. Dehydroepiandrosterone 123-145 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 49-67 21335661-2 2011 We previously identified a brain- and cell-specific oxidative stress-mediated mechanism for dehydroepiandrosterone (DHEA) biosynthesis present in rat, bovine, and human brain, independent of the cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) enzyme activity found in the periphery. Dehydroepiandrosterone 92-114 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 244-249 21335661-2 2011 We previously identified a brain- and cell-specific oxidative stress-mediated mechanism for dehydroepiandrosterone (DHEA) biosynthesis present in rat, bovine, and human brain, independent of the cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) enzyme activity found in the periphery. Dehydroepiandrosterone 116-120 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 244-249 19474057-2 2009 One suggestion is that increased DHEA production by P450c17 (CYP17A1 as listed in HUGO Database) in the ZR results from a coincident fall in the expression of HSD3B, which would otherwise compete for pregnenolone substrate. Dehydroepiandrosterone 33-37 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-59 19474057-3 2009 Nonetheless, studies of human and rhesus adrenal show that cytochrome b5 (CYTB5) expression increases in the ZR with DHEA biosynthesis, and cloned human and rhesus P450c17 show selective increases in 17,20-lyase activity in the presence of CYTB5. Dehydroepiandrosterone 117-121 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 164-171 19497978-2 2009 Cholesterol side-chain cleavage (CYP11A1) and 17alpha-hydroxylase/17,20-lyase (CYP17) metabolize cholesterol into DHEA, whereas steroid sulfotransferase family 2A1 (SULT2A1) is responsible for conversion of DHEA to DHEA sulfate. Dehydroepiandrosterone 114-118 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 79-84 19497978-2 2009 Cholesterol side-chain cleavage (CYP11A1) and 17alpha-hydroxylase/17,20-lyase (CYP17) metabolize cholesterol into DHEA, whereas steroid sulfotransferase family 2A1 (SULT2A1) is responsible for conversion of DHEA to DHEA sulfate. Dehydroepiandrosterone 207-211 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 79-84 18493130-9 2008 When both the 17alpha-hydroxylase and 17,20 lyase activities of P450c17 are present in the zona reticularis, the androgen precursor dehydroepiandrosterone is produced. Dehydroepiandrosterone 132-154 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-71 18493132-2 2008 Both hydroxylase and lyase activities of the enzyme 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) are necessary for DHEA production and are differentially regulated during adrenal development. Dehydroepiandrosterone 128-132 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 101-108 18821018-8 2009 When both the 17alpha-hydroxylase and 17,20 lyase activities of P450c17 are present in the zona reticularis, the androgen precursor DHEA is produced. Dehydroepiandrosterone 132-136 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-71 16828825-5 2006 CYP17 enzyme catalyzes an important step in sex steroidogenesis and is responsible for the biosynthesis of dehydroepiandrosterone (DHEA) and androstenedione in the adrenals. Dehydroepiandrosterone 107-129 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 16971197-6 2007 On the total cohort, a difference in endogenous DHEA levels between CYP17 homozygote A2 and non-homozygote A2; an increasing trend in AND levels from COMT L/L, L/H, to H/H; and a difference in TS level between COMT homozygote L and non-homozygote L were separately observed. Dehydroepiandrosterone 48-52 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 68-73 16971197-8 2007 In thin/normal-weight women (BMI <25 kg/m2), the same effects of CYP17 genotypes on DHEA were observed as on the total cohort. Dehydroepiandrosterone 87-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 68-73 16828825-5 2006 CYP17 enzyme catalyzes an important step in sex steroidogenesis and is responsible for the biosynthesis of dehydroepiandrosterone (DHEA) and androstenedione in the adrenals. Dehydroepiandrosterone 131-135 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 16828825-7 2006 The precursor substrate of CYP17, pregnenolone, was added to control and exposed H295R cells, and enzymatic production of DHEA was measured using a radioimmunoassay. Dehydroepiandrosterone 122-126 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 27-32 16828825-11 2006 Replacement of the 6-OH group by a 6-CH(3)O group eliminated this cytotoxic effect, but CYP17 activity measured as DHEA production was still significantly inhibited. Dehydroepiandrosterone 115-119 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 88-93 31627556-5 2005 There is evidence of the formation of DHEA in the central nervous system, where enzyme systems (P450c17) are detected in astrocytes and neurons that synthesize DHEA from pregnenolone. Dehydroepiandrosterone 38-42 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 96-103 31627556-5 2005 There is evidence of the formation of DHEA in the central nervous system, where enzyme systems (P450c17) are detected in astrocytes and neurons that synthesize DHEA from pregnenolone. Dehydroepiandrosterone 160-164 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 96-103 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Dehydroepiandrosterone 114-136 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 16103714-8 2005 Finally, 17-OH pregnenolone is converted to DHEA by the 17,20 lyase activity of P450c17. Dehydroepiandrosterone 44-48 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 80-87 15635496-3 2004 The cleavage of pregnenolone to DHEA requires both the 17alpha-hydroxylase and 17,20-lyase activities of CYP17, which is found in the endoplasmic reticulum. Dehydroepiandrosterone 32-36 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 105-110 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Dehydroepiandrosterone 114-136 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-25 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Dehydroepiandrosterone 138-142 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Dehydroepiandrosterone 138-142 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-25 14504283-5 2003 However, mutation E305G lacks 17,20-lyase activity for the conversion of 17alpha-hydroxypregnenolone to DHEA, which is the dominant pathway to C19 steroids catalyzed by human CYP17 (the delta5-steroid pathway). Dehydroepiandrosterone 104-108 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 175-180 12915666-2 2003 P450c17 can mediate testosterone biosynthesis via the conversion of pregnenolone to dehydroepiandrosterone (the delta(5) pathway) or via conversion of progesterone to androstenedione (the delta(4) pathway). Dehydroepiandrosterone 84-106 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 12788891-6 2003 The presence of 3 beta-HSD type 2 and P450c17 indicated that conversion of pregnenolone to dehydroepiandrosterone (DHEA) and to androstenedione may take place effectively in kidney. Dehydroepiandrosterone 91-113 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 38-45 12788891-6 2003 The presence of 3 beta-HSD type 2 and P450c17 indicated that conversion of pregnenolone to dehydroepiandrosterone (DHEA) and to androstenedione may take place effectively in kidney. Dehydroepiandrosterone 115-119 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 38-45 12788891-8 2003 This resulted in efficient formation of DHEA from pregnenolone, indicating both 17 alpha-hydroxylase and 17,20-lyase activities exerted by P450c17. Dehydroepiandrosterone 40-44 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 139-146 12044959-6 2002 The mechanism of dissociation of cortisol and DHEA synthesis in aging depends on another regulator of 17,20-lyase of cytochrome P450c17 such as cytochrome P450 reductase. Dehydroepiandrosterone 46-50 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 117-135 12446594-4 2002 DHEA is produced from pregnenolone by the successive 17alpha-hydroxylase and 17,20 lyase activities of a single enzyme, P450c17. Dehydroepiandrosterone 0-4 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 120-127 12573489-2 2003 In particular, the human P450c17 selectively produces dehydroepiandrosterone with little androstenedione (AD). Dehydroepiandrosterone 54-76 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 25-32 12464253-4 2003 Ovine CYP17 expressed in HEK 293 cells converts progesterone to 17-hydroxyprogesterone and pregnenolone to dehydroepiandrosterone via 17-hydroxypregnenolone. Dehydroepiandrosterone 107-129 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 6-11 12573809-6 2002 Finally, 17-OH pregnenolone is converted to DHEA by the 17,20 lyase activity of P450c17. Dehydroepiandrosterone 44-48 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 80-87 11867265-1 2002 The 17 alpha-hydroxylase and 17,20-lyase activities of P450c17 lead to the production of 17 alpha-hydroxypregnenolone (17 alpha-OH-Preg) and dehydroepiandrosterone (DHEA), respectively, in different tissues. Dehydroepiandrosterone 141-163 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 55-62 11867265-1 2002 The 17 alpha-hydroxylase and 17,20-lyase activities of P450c17 lead to the production of 17 alpha-hydroxypregnenolone (17 alpha-OH-Preg) and dehydroepiandrosterone (DHEA), respectively, in different tissues. Dehydroepiandrosterone 165-169 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 55-62 10824109-0 2000 Conversion of pregnenolone to DHEA by human 17alpha-hydroxylase/17, 20-lyase (P450c17). Dehydroepiandrosterone 30-34 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 78-85 10824109-6 2000 Using intact HEK-293 cells transfected with human P450c17 in culture, we showed, in a time course study of the transformation of pregnenolone, that there is an accumulation of 17alpha-OHPreg, and that, subsequently, the accumulated 17alpha-OHPreg decreases with a concomitant increase in DHEA production. Dehydroepiandrosterone 288-292 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 50-57 10824109-2 2000 Most previous studies using reconstituted systems and fast kinetics suggest that the conversion of pregnenolone to dehydroepiandrosterone (DHEA; the precursor of androgen and estrogen biosynthesis) by P450c17 does not require the release of the intermediate 17alpha-OHPreg (a precursor of cortisol biosynthesis). Dehydroepiandrosterone 115-137 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 201-208 10824109-2 2000 Most previous studies using reconstituted systems and fast kinetics suggest that the conversion of pregnenolone to dehydroepiandrosterone (DHEA; the precursor of androgen and estrogen biosynthesis) by P450c17 does not require the release of the intermediate 17alpha-OHPreg (a precursor of cortisol biosynthesis). Dehydroepiandrosterone 139-143 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 201-208 11117668-1 2000 Cytochrome P450c17 is a multifunctional enzyme that converts C21 steroids to the C19 sex steroid precursor DHEA. Dehydroepiandrosterone 107-111 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 10847589-3 2000 The crucial enzyme for the synthesis of DHEA (dehydroepiandrosterone) in the brain is cytochrome P450c17. Dehydroepiandrosterone 40-44 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 97-104 10847589-3 2000 The crucial enzyme for the synthesis of DHEA (dehydroepiandrosterone) in the brain is cytochrome P450c17. Dehydroepiandrosterone 46-68 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 97-104 10847589-11 2000 These studies delineate an important new factor in the transcriptional regulation of P450c17 and consequently, in the production of DHEA and sex steroids. Dehydroepiandrosterone 132-136 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 85-92