Title : Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.

Pub. Date : 2013 Nov 6

PMID : 24160919






1 Functional Relationships(s)
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1 In the formation of the male hormone dehydroepiandrosterone, pregnenolone is first hydroxylated by P450 CYP17A1 at the 17-carbon, followed a second round of catalysis by the same enzyme that cleaves the C17-C20 bond, releasing acetic acid and the 17-keto product. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens