Title : Dehydroepiandrosterone Induces Temozolomide Resistance Through Modulating Phosphorylation and Acetylation of Sp1 in Glioblastoma.

Pub. Date : 2019 Apr

PMID : 30022431






2 Functional Relationships(s)
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1 Previously, we determined that aberrantly activated cytochrome P450 17A1 causes TMZ resistance in MGMT-deficient glioblastoma by increasing the secretion of dehydroepiandrosterone (DHEA), a neurosteroid that maintains the health of neurons and astrocytes. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Previously, we determined that aberrantly activated cytochrome P450 17A1 causes TMZ resistance in MGMT-deficient glioblastoma by increasing the secretion of dehydroepiandrosterone (DHEA), a neurosteroid that maintains the health of neurons and astrocytes. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens