Title : Variation in 3β-hydroxysteroid dehydrogenase activity and in pregnenolone supply rate can paradoxically alter androstenedione synthesis.

Pub. Date : 2012 Jan

PMID : 22024430






2 Functional Relationships(s)
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1 In these species, P450c17 has negligible 17,20-lyase activity with the Delta(4)-steroid 17alpha-hydroxy-progesterone (17OH-P4); therefore androstenedione (A4) is synthesized efficiently only from dehydroepiandrosterone (DHEA) through the Delta(5) pathway. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 In these species, P450c17 has negligible 17,20-lyase activity with the Delta(4)-steroid 17alpha-hydroxy-progesterone (17OH-P4); therefore androstenedione (A4) is synthesized efficiently only from dehydroepiandrosterone (DHEA) through the Delta(5) pathway. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens