Pub. Date : 2017 Oct
PMID : 28707358
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CNS tissues from patients with MS and animals with experimental autoimmune encephalomyelitis (EAE) displayed reduced DHEA concentrations, accompanied by diminished expression of the DHEA-synthesizing enzyme CYP17A1 in oligodendrocytes (ODCs), in association with increased expression of inflammatory genes including interferon (IFN)-gamma and interleukin (IL)-1beta. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Thus, CYP17A1 expression in ODCs and its product DHEA were downregulated in the CNS during inflammatory demyelination while DHEA-S provision suppressed neuroinflammation, demyelination, and axonal injury that was evident as improved neurobehavioral performance. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |