Pub. Date : 2021
PMID : 34377232
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phenformin synergistically sensitizes liver cancer cells to sorafenib by downregulating CRAF/ERK and PI3K/AKT/mTOR pathways. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Phenformin further bolstered the ability of sorafenib to inhibit the CRAF/ERK and PI3K/AKT/mTOR pathways. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Sorafenib and phenformin can synergistically suppress CRAF/ERK and PI3K/AKT/mTOR pathway activation in HCC cells, and may thus represent a promising approach to treating this deadly cancer. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |