Pub. Date : 2019 Sep
PMID : 31233204
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic antitumor effect of BRMS1 and sorafenib via inhibition of the PI3K/AKT/mTOR/ERK signaling pathway. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, expression of inflammatory response-related genes was increased, while secretion of angiogenesis-related molecules was decreased, and apoptosis was also activated after sorafenib treatment using qPCR method, and it was further demonstrated that this effect was mediated by inhibition of the PI3K/AKT/mTOR/ERK signaling pathway using western blot analysis. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, overexpression of BRMS1 potentiated the effect of sorafenib via PI3K/AKT/mTOR/ERK signaling, while knockdown of BRMS1 expression attenuated this effect. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |