Pub. Date : 2019 Aug
PMID : 31233189
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of AKT/AP1/FoxM1 signaling confers sorafenib resistance to liver cancer cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Inhibition of AKT using BEZ-235 markedly suppressed the upregulation of c-jun and FoxM1, and increased the sensitivity of drug-resistant cells to sorafenib in vitro and in vivo. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | The data indicated that the activation of the AKT/AP1/FoxM1 signaling axis is an important determinant of sorafenib tolerance. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |