Pub. Date : 2018 Jan
PMID : 29156516
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib in hepatocellular carcinoma by modulating PTEN/Akt signaling pathway. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | However, PI3K/Akt signaling pathway is activated by Sorafenib and cross-talks with the Raf/MAPK/ERK signaling pathway, leading to drug resistance. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Hence, we aim to examine the synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib via modulation of PTEN/Akt signaling pathway. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | The levels of PTEN, Bax and cleaved caspase-3 expression increased, while the levels of phospho-PDK1 and phospho-Akt expression decreased by the treatment of Sorafenib combined with 20(S)-Ginsenoside Rg3. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | The results demonstrated the synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib in HCC by modulating PTEN/Akt signaling pathway. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |