Pub. Date : 2019 May 3
PMID : 31053148
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The present study aims to explore the involvement of lncRNA SNHG1 (small nucleolar RNA host gene 1) in sorafenib resistance and how SNHG1 is associated with overexpressed microRNA-21 (miR-21) and the activated Akt pathway, which have been demonstrated to mediate this resistance in HCC cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Overexpressed SNHG1 contributes to sorafenib resistance by activating the Akt pathway via regulating SLC3A2. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Depletion of SNHG1 enhanced the efficacy of sorafenib to induce apoptosis and autophagy of SR-HCC cells by inhibiting the activation of Akt pathway. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Sorafenib induced translocation of miR-21 to the nucleus, where it promoted the expression of SNHG1, resulting in upregulation of SLC3A2, leading to the activation of Akt pathway. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | CONCLUSIONS: The present study has demonstrated that lncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and its nuclear expression is promoted by miR-21, whose nuclear translocation is induced by sorafenib. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | CONCLUSIONS: The present study has demonstrated that lncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and its nuclear expression is promoted by miR-21, whose nuclear translocation is induced by sorafenib. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |