Pub. Date : 2021 Aug
PMID : 33015852
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Valproic acid reverses Sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in HCC. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Thorough comparisons of the molecular changes between parental HepG2 and sorafenib-resistant HepG2-SR cells indicated that the Notch signaling pathway and PI3K/Akt signaling pathway were associated with sorafenib resistance mechanisms. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Thorough comparisons of the molecular changes between parental HepG2 and sorafenib-resistant HepG2-SR cells indicated that the Notch signaling pathway and PI3K/Akt signaling pathway were associated with sorafenib resistance mechanisms. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Notch1 and Akt were up-regulated in sorafenib-resistant cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | However, we surprisingly found that VPA combined with sorafenib could enhance the sensitivity of drug-resistant cells and reverse the increased levels of Notch1 and Akt in sorafenib-resistant HCC cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | However, we surprisingly found that VPA combined with sorafenib could enhance the sensitivity of drug-resistant cells and reverse the increased levels of Notch1 and Akt in sorafenib-resistant HCC cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | Collectively, our results indicated that Notch1 and Akt might play vital roles in sorafenib resistance in HCC cells and VPA might overcome the drug resistance to enhance the sensitivity of HCC cells to sorafenib through suppressing Notch/Akt signaling pathway. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |